引言在基因疗法中，腺相关病毒（Adeno-associated viruses, AAVs）无疑是当今最耀眼的载体明星。它安全、低免疫原性、能感染分裂和非分裂细胞，被视为治疗遗传性疾病的“黄金马车”。然而，这辆马车有一个致命的阿喀琉斯之踵：它的“后备箱”太小了。AAV 的衣壳仅能容纳约 4.7 kb 的遗传物质。这一物理限制，将包括 ...

Delivery of therapeutic genes is essential for gene therapy. Adeno-associated viruses (AAVs) are a prime vector for carrying ...

When the genomes of parents come together to create the genome of a child, their DNA recombines; similar parts are rearranged so that a child carries sections of their parents genomes that have been ...

Delivery of therapeutic genes is essential for gene therapy. Adeno-associated viruses (AAVs) are a prime vector for carrying gene cargoes because of ...

Tokyo, Japan – Researchers from Tokyo Metropolitan University have been studying DNA repair by homologous recombination, where the RecA protein repairs breaks in double-stranded DNA by incorporating a ...

Recombinant DNA (rDNA) refers to artificial DNA molecules that are created by combining genetic material from different sources. This technology involves the insertion of DNA fragments from one ...

In a new study published in the Journal of Hepatology, researchers from the San Raffaele Telethon Institute for Gene Therapy (SR-Tiget) show that only 15–20% of hepatocytes in newborn mice—dubbed ...

Distinguishing Renal Cell Carcinoma From Normal Kidney Tissue Using Mass Spectrometry Imaging Combined With Machine Learning Homologous recombination DNA repair deficiency (HRD) is a therapeutic ...

DDIR/HRD classification is highly prognostic in TNBC and identifies biologically and immunologically distinct subgroups. Immune-enriched DDIR+/HRD+ TNBCs have the most favorable prognosis, and ...